Healing Category
Cortagen
THE ADRENAL SUPPORTER
Peptide Complex AEDP
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) that supports both brain and heart health. It works by entering neurons and heart cells to modify gene expression, promoting repair and stress resistance. It's studied for traumatic brain injury, nerve regeneration, and cardiac protection after stress.
Cortagen Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- No established regimen
- Linked evidence
- 1 research sources
- Content updated
- Sep 15, 2026
Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Cortagen
Is Cortagen FDA approved?
No. This profile records Cortagen as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What research supports this Cortagen guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Cortagen research sourcesWhat are the side effects of Cortagen?
We don't list specific side effects for Cortagen.
Is Cortagen safe?
Cortagen has an editorial safety grade of A (Excellent Safety).
More context
Well-tolerated synthetic peptide from the Khavinson family. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
Epigenetic Regulation
Opens chromatin for transcription of repair genes
Neurotrophin Boost
Increases BDNF and NGF for nerve growth and repair
Cardiac Protection
Activates stress-resistance genes in heart tissue
Antioxidant
Upregulates Nrf2 pathway for cellular protection
Design informed by a cortex extract
Anisimov, Khavinson and colleagues described Cortagen's design in a 2004 paper. They reported synthesizing the four-residue sequence Ala-Glu-Asp-Pro using amino-acid analysis of the brain-cortex preparation Cortexin as a starting point. Cortagen is the defined synthetic sequence; Cortexin is the source preparation that informed that work, not another name for the same molecule.
[Anisimov, Khavinson and colleagues, Cortagen design background, 2004](https://pubmed.ncbi.nlm.nih.gov/15159690/)
Who is this for
People recovering from brain injury · Those with nerve damage needing regeneration · People under chronic stress · Those seeking brain-heart health optimization
Cortagen price snapshot
In-stock prices from 13 vendors, checked Oct 14, 2026.
- Vendors
- 13
- Listings
- 13
- Observed range
- $41–$63
Market evidence
Cortagen product testing and COAs
We found certificates from some of the Cortagen vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Cortagen research
The clinic network
Want a clinician's view on Cortagen?
Request a free connection to a peptide clinic, by telehealth or in person. A licensed clinician decides whether any treatment is right for you. What peptide therapy involves
Related Peptides
Pinealon
THE DREAMWEAVERAHighNeurological Support · Sleep RegulationCognitive · Neurological SupportDose1 mg↻CycleA firsthand report used a 20-day course; no...◷Kicks inSleep improvements often noticed within the...Sleep like you mean it and wake up mentally sharp.
from $1.70/mg · 121 vendorsNº 005 / 006SS-31
THE MITOCHONDRIAL OPTIMIZERBGoodCardiovascular Support · Neurological SupportHealing · Cardiovascular SupportDose5 mg↻CycleNo clinically established cycle for this...◷Kicks inEnergy improvements may be noticed within...Directly target and repair your mitochondria
from $1.35/mg · 190 vendorsNº 006 / 006Chelohart
THE HEART GUARDIANAHighCardiovascular Support · BioregulatorLongevity · Cardiovascular SupportDoseSee guide↻CycleNo established SubQ dosing cycle.◷Kicks inCardiac improvements develop over the full...Strengthen your heart at the cellular level
Full profileNº 001 / 006Humanin
THE CELLULAR GUARDIANBGoodMetabolic Modulator · Cardiovascular SupportMetabolic · Metabolic ModulatorDose500 mcg↻CycleExperimental. As directed◷Kicks inProtective effects observed in animal...Mitochondrial peptide for brain, heart, and metabolic protection
from $5.44/mg · 21 vendorsNº 002 / 006L-Carnitine
THE FAT TRANSPORTERAHighMetabolic Modulator · Mitochondrial SupportMetabolic · Metabolic ModulatorDoseSee guide↻CycleOngoing or as needed◷Kicks inEnergy improvements often noticed within 1-2...Fat-burning amino acid for energy and mitochondrial health
from $0.05/mg · 28 vendorsNº 003 / 006Normoftal
THE VISION PROTECTORAHighNeurological Support · AntioxidantHealing · Neurological SupportDoseSee guide↻CycleNo established SubQ dosing cycle.◷Kicks inVision improvements may be subtle and...Protect and restore your retinal health naturally
Full profileNº 004 / 006