Healing Category
Cortagen
THE ADRENAL SUPPORTER
Peptide Complex AEDP
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) that supports both brain and heart health. It works by entering neurons and heart cells to modify gene expression, promoting repair and stress resistance. It's studied for traumatic brain injury, nerve regeneration, and cardiac protection after stress.
Cortagen Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 2 research sources
- Content updated
- Sep 15, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Cortagen
Is Cortagen FDA approved?
No. This profile records Cortagen as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for Cortagen?
Dose: No established SubQ regimen..
More context
Cycle: No established SubQ dosing cycle.. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Cortagen guide?
This guide links to 2 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Cortagen research sourcesStudied Effects & Mechanisms
Epigenetic Regulation
Opens chromatin for transcription of repair genes
Neurotrophin Boost
Increases BDNF and NGF for nerve growth and repair
Cardiac Protection
Activates stress-resistance genes in heart tissue
Antioxidant
Upregulates Nrf2 pathway for cellular protection
Design informed by a cortex extract
Anisimov, Khavinson and colleagues described Cortagen's design in a 2004 paper. They reported synthesizing the four-residue sequence Ala-Glu-Asp-Pro using amino-acid analysis of the brain-cortex preparation Cortexin as a starting point. Cortagen is the defined synthetic sequence; Cortexin is the source preparation that informed that work, not another name for the same molecule.
[Anisimov, Khavinson and colleagues, Cortagen design background, 2004](https://pubmed.ncbi.nlm.nih.gov/15159690/)
Who is this for
People recovering from brain injury · Those with nerve damage needing regeneration · People under chronic stress · Those seeking brain-heart health optimization
Further listening
1 recordingResearch-Market Price Snapshot
A compact market signal for this profile. The dedicated pricing page owns vendor, vial-size, and price-per-mg comparisons.
Updated Oct 5, 2026
- Vendors
- 14
- Listings
- 14
- Observed range
- $41–$70
Market evidence
Cortagen product testing and COAs
Current certificates are on file for 8 of 19 vendors tracked in the Cortagen market. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Cortagen Research
Live research temporarily unavailable
The live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
Research references
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