Cognitive Category
Vesugen
THE VESSEL PROTECTOR
A-7 Vascular Endothelium Bioregulator Peptide, KED
Vesugen is a synthetic tripeptide (Lys-Glu-Asp) that specifically targets the endothelium, the inner lining of your blood vessels. It reverses age-related declines in vascular elasticity, enhances nitric oxide production, and supports both cardiovascular and cognitive health by improving blood flow throughout the body.
Vesugen Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- No established regimen
- Linked evidence
- 2 research sources
- Content updated
- Sep 15, 2026
Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Vesugen
Is Vesugen FDA approved?
No. This profile records Vesugen as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What research supports this Vesugen guide?
This guide links to 2 curated or current research sources.
More context
Inspect the research section and the citations beneath the research answers for their supporting sources.
Review the Vesugen research sourcesWhat are the side effects of Vesugen?
Reported side effects of Vesugen include Rare mild hypotension and Dizziness in sensitive individuals.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Vesugen safe?
Vesugen has an editorial safety grade of B (Good Safety).
More context
Well-tolerated synthetic tripeptide with minimal side effects. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
What did research find about Vesugen and neuronal differentiation of human periodontal ligament stem cells?
Vesugen, which is also called Lys-Glu-Asp (KED), was studied in cultured human periodontal ligament stem cells (hPDLSCs) for its effect on neuronal differentiation using immunofluorescence and western blot analysis. In these in vitro studies, the compound of peptides AEDG, KE, AED and KED was reported to promote neuronal differentiation of hPDLSCs, with KED being one of the four peptides in that compound. In hPDLSCs cultures, KED increased the expression of Nestin, a neurofilament protein expressed in early neuronal precursors.
Studied Effects & Mechanisms
Endothelial Gene Activation
Upregulates eNOS, KLF2, VE-cadherin, and SIRT1 via epigenetic modification
Anti-Inflammatory
Suppresses NF-κB and STAT3 signaling, reducing adhesion molecules
Matrix Integrity
Upregulates elastin and collagen IV for vascular structure
Short-peptide research lineage
Vesugen is identified as Lys-Glu-Asp in a 2012 paper by Vladimir Khavinson and colleagues from the Pavlov Institute of Physiology in St. Petersburg. The study compared several short peptides in cell cultures. Lys-Glu-Asp, abbreviated KED, is a three-residue sequence; the related names used for other short peptides do not make their sequences interchangeable.
[Khavinson and colleagues, short-peptide cell-culture study, 2012](https://pubmed.ncbi.nlm.nih.gov/22808515/)
Who is this for
People with hypertension or vascular stiffness · Those recovering from stroke or ischemic events · Anyone wanting to protect blood vessels during aging · People with cognitive decline related to poor circulation · Those with microvascular disease or diabetes
Vesugen price snapshot
In-stock prices from 23 vendors, checked Oct 14, 2026.
- Vendors
- 23
- Listings
- 24
- Observed range
- $35–$100
Market evidence
Vesugen product testing and COAs
We found certificates from some of the Vesugen vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Vesugen research
The clinic network
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