Metabolic Category
Mazdutide
THE DUAL ACTIVATOR
OXM3; IBI362; LY3305677
Mazdutide is a dual GLP-1/glucagon receptor agonist being developed for obesity and type 2 diabetes. Unlike single-target drugs like semaglutide, it activates both receptors for potentially greater weight loss. The GLP-1 action reduces appetite and slows digestion, while glucagon activation increases energy expenditure and fat burning.
Mazdutide Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- Sep 10, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Mazdutide
Is Mazdutide FDA approved?
No. This profile records Mazdutide as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for Mazdutide?
Dose: Start at 1.5 mg once weekly (subcutaneous injection), with gradual titration up to 6 mg once weekly..
More context
Schedule: weekly. Cycle: Ongoing as prescribed in clinical trials. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Mazdutide guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Mazdutide research sourcesWhat are the side effects of Mazdutide?
Reported side effects of Mazdutide include Nausea, Vomiting, Diarrhea, Injection site reactions, and Decreased appetite.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Mazdutide safe?
Mazdutide has an editorial safety grade of C (Moderate Safety).
More context
Still in clinical trials. Similar side effect profile to other GLP-1 drugs. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
Appetite Suppression
GLP-1 activation reduces hunger and food intake
Increased Thermogenesis
Glucagon receptor activation boosts energy expenditure
Glucose Control
Improves insulin secretion and blood sugar regulation
Gastric Slowing
Delays stomach emptying for prolonged satiety
Oxyntomodulin-based structure
Mazdutide is described in the research literature as a synthetic analogue of oxyntomodulin with an attached fatty-acid side chain. Earlier research documents use the identifiers IBI362 and LY3305677 for the same development compound. Oxyntomodulin provides the peptide starting point for this design, which differs from simply combining two separate peptide products.
[Mazdutide structural description in the trial report, 2023](https://pmc.ncbi.nlm.nih.gov/articles/PMC10719339/)
Who is this for
Those with significant weight to lose · People with type 2 diabetes · Those who haven't responded well to GLP-1 alone · Those interested in cutting-edge obesity treatments
Mazdutide price snapshot
In-stock prices from 24 vendors, checked Oct 14, 2026.
- Vendors
- 24
- Listings
- 30
- Observed range
- $50–$250
Market evidence
Mazdutide product testing and COAs
We found certificates from some of the Mazdutide vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Mazdutide research
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