Healing Category
PNC-27
THE CANCER TERMINATOR
HDM-2 Binding Peptide
PNC-27 is a synthetic peptide designed to selectively kill cancer cells while leaving healthy cells unharmed. It works by binding to HDM-2, a protein that cancer cells overexpress on their surface, and then forming pores in their membranes. This liberates the p53 tumor suppressor, allowing it to trigger cancer cell death. It's being researched for various cancers.
PNC-27 Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- Aug 28, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About PNC-27
Is PNC-27 FDA approved?
No. This profile records PNC-27 as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for PNC-27?
Dose: 250 mcg daily (research protocol).
More context
Schedule: daily. Cycle: 6 weeks on, 8 weeks off. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this PNC-27 guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the PNC-27 research sourcesWhat are the side effects of PNC-27?
Reported side effects of PNC-27 include Injection site irritation and Unknown systemic effects.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is PNC-27 safe?
PNC-27 has an editorial safety grade of D (Caution Advised).
More context
Not approved for clinical use. Safety profile not established in humans. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
HDM-2 Binding
Binds to HDM-2 protein overexpressed on cancer cells
p53 Liberation
Frees p53 tumor suppressor to activate apoptosis
Membrane Pores
Forms channels in cancer cell membranes causing necrosis
Selectivity
Spares healthy cells lacking HDM-2 overexpression
A joined p53-derived research construct
PNC-27 joins residues 12 through 26 of the p53 protein to a membrane-penetrating leader sequence at its C-terminal end. The original 2001 study compared this construct with other p53-derived peptides carrying different segments. The joined domains explain its description as a chimeric peptide; the construct is not full-length p53.
[Kanovsky and colleagues, p53-derived peptide design, 2001](https://pmc.ncbi.nlm.nih.gov/articles/PMC60072/)
Who is this for
Those exploring adjunctive cancer therapies · Those with cancers overexpressing HDM-2 · Anyone researching selective anti-cancer peptides
PNC-27 price snapshot
In-stock prices from 32 vendors, checked Oct 14, 2026.
- Vendors
- 32
- Listings
- 36
- Observed range
- $35–$280
Market evidence
PNC-27 product testing and COAs
We found certificates from some of the PNC-27 vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
PNC-27 research
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