THE WAKEFULNESS PROMOTER
Orexin A and Orexin B
Master regulators of wakefulness, appetite, and energy
Also known as: Hypocretins
Overview
Orexins are neuropeptides produced in your hypothalamus that control wakefulness, hunger, and stress responses. Orexin deficiency causes narcolepsy - that's how important they are for staying awake and alert. Supplementing with orexins can boost daytime alertness, regulate appetite, and help normalize disrupted sleep-wake cycles.
Key Benefits & Mechanisms
Wake Promotion
Activates wake-promoting neurons in the hypothalamus
Appetite Regulation
Modulates hunger signals through NPY/AgRP pathways
Cognitive Enhancement
Improves attention and cognitive performance
Stress Response
Modulates HPA axis and sympathetic nervous system
Dosing Guide
Dosage
100 mcg intranasally each morning
Schedule
daily
Cycle
4 weeks on, 4 weeks off
Pro Tip
Take in the morning to enhance wakefulness without affecting nighttime sleep
Safety Profile
Good Safety
Good
Well studied with generally manageable side effects.
May cause insomnia if taken too late. Research is ongoing.
Possible Side Effects
What to Expect
Day 1-3
Increased alertness and wakefulness
Week 1
Improved daytime energy and focus
Week 2-4
Stabilized sleep-wake cycle and appetite
Alertness improvements typically noticed within the first few days.
Who Is This For
Research References
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