Metabolic Category
Orexin A and Orexin B
THE WAKEFULNESS PROMOTER
Hypocretins
Orexins are neuropeptides produced in your hypothalamus that control wakefulness, hunger, and stress responses. Orexin deficiency causes narcolepsy. That's how important they are for staying awake and alert. Supplementing with orexins can boost daytime alertness, regulate appetite, and help normalize disrupted sleep-wake cycles.
Orexin A and Orexin B Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- Aug 28, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Orexin A and Orexin B
Is Orexin A and Orexin B FDA approved?
No. This profile records Orexin A and Orexin B as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for Orexin A and Orexin B?
Dose: 100 mcg intranasally each morning.
More context
Schedule: daily. Cycle: 4 weeks on, 4 weeks off. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Orexin A and Orexin B guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Orexin A and Orexin B research sourcesStudied Effects & Mechanisms
Wake Promotion
Activates wake-promoting neurons in the hypothalamus
Appetite Regulation
Modulates hunger signals through NPY/AgRP pathways
Cognitive Enhancement
Improves attention and cognitive performance
Stress Response
Modulates HPA axis and sympathetic nervous system
Who is this for
Those with excessive daytime sleepiness · People wanting sharper daytime alertness · Those with disrupted circadian rhythms · People interested in appetite regulation · Night shift workers needing schedule adjustment
Research-Market Price Snapshot
A compact market signal for this profile. The dedicated pricing page owns vendor, vial-size, and price-per-mg comparisons.
Updated Aug 30, 2026
- Vendors
- 2
- Listings
- 2
- Observed range
- $119–$262
Market evidence
Orexin A and Orexin B product testing and COAs
Current certificates are on file for 1 of 2 vendors tracked in the Orexin A and Orexin B market. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Orexin A and Orexin B Research
Live research temporarily unavailable
The live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
Research references
Related Peptides
DSIP
THE SLEEP INDUCERBGoodNeurological Support · Sleep RegulationCognitive · Neurological SupportDoseSee guide↻CycleAs needed for sleep support◷Kicks inSleep quality improvements often noticed...Natural sleep peptide for deep rest and stress relief
from $2.67/mg · 79 vendorsNº 002 / 006Epitalon
THE LONGEVITY FACTORAHighNeurological Support · Sleep RegulationHealing · Neurological SupportDose1 mg↻Cycle10-30 days on, 4-6 months off◷Kicks inSleep improvements within days; telomere...Supports cellular longevity and circadian rhythm for optimal sleep-based brain repair.
from $1.14/mg · 113 vendorsNº 003 / 006Pinealon
THE DREAMWEAVERAHighNeurological Support · Sleep RegulationCognitive · Neurological SupportDose1 mg↻Cycle4 weeks on, 8 weeks off◷Kicks inSleep improvements often noticed within the...Sleep like you mean it and wake up mentally sharp.
from $0.90/mg · 62 vendorsNº 005 / 006BPC-157
THE HEALERAHighAccelerated Healing · Neurological SupportHealing · Accelerated HealingDose250 mcg↻Cycle4-8 weeks on, then equal break◷Kicks inRecovery improvements often noticed within...Accelerates healing of tendons, ligaments, gut, and muscles throughout your body.
from $2/mg · 175 vendorsNº 001 / 006GHK-Cu
THE RESTORERAHighAccelerated Healing · Neurological SupportHealing · Accelerated HealingDose500 mcg↻CycleVariable: topical ongoing, injectable cycled◷Kicks inSkin improvements within 2-4 weeks; hair...Copper peptide that rebuilds collagen for skin, hair, and healing.
from $0.03/mg · 161 vendorsNº 004 / 006PT-141
THE DESIRE ACTIVATORCModerateNeurological Support · Sexual & Reproductive HealthHealing · Neurological SupportDose1.5 mg↻CycleAs needed, max 1 dose per 24 hours, max 8...◷Kicks inEffects typically begin 45-60 minutes after...FDA-approved desire enhancement that works through the brain
from $2.20/mg · 94 vendorsNº 006 / 006