THE WAKEFULNESS PROMOTER

Orexin A and Orexin B

Grade B — Good

Master regulators of wakefulness, appetite, and energy

Also known as: Hypocretins

Neurological Support
Sleep Regulation
Appetite & Metabolic Control

Overview

Orexins are neuropeptides produced in your hypothalamus that control wakefulness, hunger, and stress responses. Orexin deficiency causes narcolepsy - that's how important they are for staying awake and alert. Supplementing with orexins can boost daytime alertness, regulate appetite, and help normalize disrupted sleep-wake cycles.

Key Benefits & Mechanisms

Wake Promotion

Activates wake-promoting neurons in the hypothalamus

Appetite Regulation

Modulates hunger signals through NPY/AgRP pathways

Cognitive Enhancement

Improves attention and cognitive performance

Stress Response

Modulates HPA axis and sympathetic nervous system

Dosing Guide

Dosage

100 mcg intranasally each morning

Schedule

daily

Cycle

4 weeks on, 4 weeks off

Pro Tip

Take in the morning to enhance wakefulness without affecting nighttime sleep

Safety Profile

B

Good Safety

Good

Well studied with generally manageable side effects.

May cause insomnia if taken too late. Research is ongoing.

Possible Side Effects

Headache
Insomnia (if taken late)

What to Expect

Day 1-3

Increased alertness and wakefulness

Week 1

Improved daytime energy and focus

Week 2-4

Stabilized sleep-wake cycle and appetite

Alertness improvements typically noticed within the first few days.

Who Is This For

Those with excessive daytime sleepiness
People wanting sharper daytime alertness
Those with disrupted circadian rhythms
People interested in appetite regulation
Night shift workers needing schedule adjustment

Research References

[1]Sakurai et al. 1998 - Discovery of Orexins

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