Healing Category
Vasoactive Intestinal Peptide (VIP)
THE MULTI-SYSTEM HEALER
VIP, Aviptadil, PHM27
VIP is a versatile 28-amino-acid neuropeptide that acts as a master regulator of inflammation throughout your body. It protects the brain, heals the gut, supports lung function, and calms overactive immune responses. It's particularly effective for Chronic Inflammatory Response Syndrome (CIRS), mold illness, and complex multi-system inflammatory conditions.
Vasoactive Intestinal Peptide (VIP) Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- No established regimen
- Linked evidence
- 4 research sources
- Content updated
- Sep 15, 2026
Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Vasoactive Intestinal Peptide (VIP)
Is Vasoactive Intestinal Peptide (VIP) FDA approved?
No. This profile records Vasoactive Intestinal Peptide (VIP) as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What research supports this Vasoactive Intestinal Peptide (VIP) guide?
This guide links to 4 curated or current research sources.
More context
Inspect the research section and the citations beneath the research answers for their supporting sources.
Review the Vasoactive Intestinal Peptide (VIP) research sourcesWhat are the side effects of Vasoactive Intestinal Peptide (VIP)?
Reported side effects of Vasoactive Intestinal Peptide (VIP) include Dizziness, Headache, Irritability, Rash, and Low blood pressure.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Vasoactive Intestinal Peptide (VIP) safe?
Vasoactive Intestinal Peptide (VIP) has an editorial safety grade of B (Good Safety).
More context
Well-studied neuropeptide with good safety profile when used appropriately. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
How does VIP act in the lungs according to laboratory studies?
In nonclinical laboratory studies, VIP was reported to upregulate surfactant production in pulmonary cells. In those same studies, VIP was reported to inhibit cytokine synthesis and prevent cytopathy in pulmonary cells. VIP was also reported to block replication of SARS-CoV-2 in pulmonary cells in these studies. Based on these properties, the source suggests that inhaled aviptadil may have the potential to prevent ARDS in COVID-19.
- The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled Trial.
- Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial.
Studied Effects & Mechanisms
NF-κB Suppression
Powerfully reduces inflammatory signaling and cytokine production
Neuroprotection
Preserves blood-brain barrier and reduces beta-amyloid deposits
Gut Barrier Repair
Increases zonulin-1 and tight junction proteins to heal leaky gut
Pulmonary Protection
Supports lung tissue repair and reduces pulmonary inflammation
Where the VIP name came from
Sami Said and Viktor Mutt reported the isolation of VIP from intestinal tissue in 1970. Their subsequent chemical work described a 28-residue peptide related to secretin and glucagon. The intestinal name reflects the tissue used in that early isolation work; it is part of the molecule's discovery history.
[Said and Mutt, initial isolation report, 1970](https://www.nature.com/articles/225863a0)
[Said and Mutt, peptide characterization, 1972](https://doi.org/10.1111/j.1432-1033.1972.tb01903.x)
Who is this for
People with CIRS or mold illness · Those with chronic gut inflammation (IBD, IBS) · Anyone with neuroinflammation or brain fog · People with pulmonary fibrosis or lung inflammation · Those with complex autoimmune or inflammatory conditions
Vasoactive Intestinal Peptide (VIP) price snapshot
In-stock prices from 72 vendors, checked Oct 14, 2026.
- Vendors
- 72
- Listings
- 81
- Observed range
- $20–$990
Market evidence
Vasoactive Intestinal Peptide (VIP) product testing and COAs
We found certificates from some of the Vasoactive Intestinal Peptide (VIP) vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Vasoactive Intestinal Peptide (VIP) research
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