Metabolic Category
Tesofensine
THE APPETITE CRUSHER
TE-1; NS2330
Tesofensine is a triple monoamine reuptake inhibitor that was originally developed for Parkinson's and Alzheimer's. It blocks reuptake of dopamine, norepinephrine, and serotonin, powerfully reducing appetite and increasing energy expenditure. In trials it produced greater weight loss than any other single agent, making it one of the most effective compounds for obesity.
Tesofensine Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- Aug 28, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Tesofensine
Is Tesofensine FDA approved?
No. This profile records Tesofensine as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for Tesofensine?
Dose: 0.25-0.5 mg orally once daily.
More context
Schedule: daily. Cycle: Ongoing with medical supervision. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Tesofensine guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Tesofensine research sourcesStudied Effects & Mechanisms
Triple Reuptake Inhibition
Blocks DAT, NET, and SERT transporters
Appetite Suppression
Increases monoamines in hypothalamic feeding centers
Thermogenesis
Enhances sympathetic activity and energy expenditure
Cognitive Enhancement
Improves dopamine-mediated focus and motivation
Who is this for
Those with significant weight to lose · People who struggle with appetite control · Those who haven't responded to other weight loss drugs · Anyone wanting cognitive boost alongside weight loss
Research-Market Price Snapshot
A compact market signal for this profile. The dedicated pricing page owns vendor, vial-size, and price-per-mg comparisons.
Live pricing
The live pricing feed did not return ready in-stock rows for this peptide.
Open the dedicated pricing page →Market evidence
Tesofensine product testing and COAs
Current certificates are on file for 9 of 25 vendors tracked in the Tesofensine market. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Tesofensine Research
Live research temporarily unavailable
The live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
Research references
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