Metabolic Category
Tesofensine
THE APPETITE CRUSHER
TE-1; NS2330
Tesofensine is a triple monoamine reuptake inhibitor that was originally developed for Parkinson's and Alzheimer's. It blocks reuptake of dopamine, norepinephrine, and serotonin, powerfully reducing appetite and increasing energy expenditure. In trials it produced greater weight loss than any other single agent, making it one of the most effective compounds for obesity.
Key Benefits & Mechanisms
Triple Reuptake Inhibition
Blocks DAT, NET, and SERT transporters
Appetite Suppression
Increases monoamines in hypothalamic feeding centers
Thermogenesis
Enhances sympathetic activity and energy expenditure
Cognitive Enhancement
Improves dopamine-mediated focus and motivation
Who Is This For
Those with significant weight to lose · People who struggle with appetite control · Those who haven't responded to other weight loss drugs · Anyone wanting cognitive boost alongside weight loss · People interested in metabolic enhancement
Tesofensine Research Use Only Market Pricing
View all Tesofensine price observationsUpdated Jun 12, 2026
Vendors
2
Listings
2
Low Price
$121
High Price
$150
Common Vial Sizes
Tesofensine Research
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Research references
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