Metabolic Category
Setmelanotide
THE GENETIC HUNGER CONTROLLER
RM-493; Imcivree
Setmelanotide (Imcivree) is a highly selective MC4R agonist FDA-approved for rare genetic obesity disorders like POMC, PCSK1, and LEPR deficiency. It works by activating the melanocortin-4 receptor to restore satiety signaling that's broken in these genetic conditions. It produces dramatic weight loss in patients who previously had no treatment options.
Setmelanotide Evidence Snapshot
How these guides are reviewed- Regulatory status
- FDA-approved uses exist
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 3 research sources
- Content updated
- Jul 13, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Setmelanotide
Is Setmelanotide FDA approved?
This profile records Setmelanotide as FDA approved.
More context
Approval can be specific to a formulation, indication, and prescribing context, so review the regulatory and source details on this page.
What dose does The Peptide App Clinical Team recommend for Setmelanotide?
Dose: 3 mg daily subcutaneously.
More context
Schedule: daily. Cycle: Ongoing as prescribed. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Setmelanotide guide?
This guide links to 3 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Setmelanotide research sourcesWhat are the side effects of Setmelanotide?
Reported side effects of Setmelanotide include Injection site reactions, Hyperpigmentation, Nausea, and Increased heart rate.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Setmelanotide safe?
Setmelanotide has an editorial safety grade of B (Good Safety).
More context
FDA-approved with manageable side effects. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
MC4R Activation
Selectively activates melanocortin-4 receptors
Satiety Restoration
Bypasses genetic defects to restore fullness signals
Thermogenesis
Increases sympathetic tone and energy expenditure
Genetic Bypass
Works downstream of POMC/LEPR genetic defects
An eight-residue cyclic structure
Setmelanotide is a synthetic analogue of alpha-melanocyte-stimulating hormone. It contains eight amino-acid residues and an internal disulfide bond connecting the cysteines at positions 2 and 8. The peptide also has an acetylated N-terminus and an amidated C-terminus. These are features of the molecule itself, separate from the other ingredients in a finished formulation.
[FDA chemistry assessment, molecular structure, 2020](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213793Orig1s000ChemR.pdf)
Who is this for
Patients with POMC deficiency obesity · Those with PCSK1 deficiency obesity · Patients with LEPR deficiency obesity · Anyone with diagnosed genetic obesity syndrome · Those who failed other obesity treatments due to genetics
Setmelanotide price snapshot
In-stock prices from 1 vendor, checked Oct 14, 2026.
- Vendors
- 1
- Listings
- 1
- Observed range
- $60–$60
Market evidence
Setmelanotide product testing and COAs
We found no certificates from the Setmelanotide vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Setmelanotide research
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