Healing Category
THE NATURAL ANTIBIOTIC
Cathelicidin Antimicrobial Peptide
LL-37 is part of your innate immune system: a natural antimicrobial peptide that kills bacteria, viruses, and fungi by punching holes in their membranes. It also modulates immune responses and promotes wound healing. Supplementing may help fight infections and support immune function.
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
No. This profile records LL-37 as not FDA approved and for research use only.
Review the regulatory and source details on this page for the current context.
Dose: Topical or injectable.
Dosing varies by application. Schedule: daily. Cycle: As needed for infections or wounds. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
This guide links to 4 curated or current research sources.
Inspect the research section and the citations beneath the research answers for their supporting sources.
Review the LL-37 research sourcesReported side effects of LL-37 include Injection site reactions and Potential inflammation if overused.
They are reported or occasional reactions, not a prediction of what any one person will experience.
LL-37 has an editorial safety grade of B (Good Safety).
Naturally occurring human peptide. Generally well-tolerated. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
LL-37 is a human cathelicidin antimicrobial peptide naturally present in saliva, described as playing an important role in host defence against bacterial and fungal pathogens. A review describes LL-37 as an antimicrobial peptide involved in antimicrobial defence, inflammatory regulation, tissue repair, and bone regeneration in the oral cavity. More generally, cathelicidin-derived antimicrobial peptides such as LL-37 are described as part of the first line of defense of the innate immune system.
Punches holes in bacterial and viral membranes
Regulates inflammatory responses through TLR signaling
Promotes angiogenesis and tissue repair
LL-37 is produced by cleavage of a larger precursor protein called hCAP18. A 2001 study of human neutrophils identified proteinase 3 as the enzyme responsible for releasing LL-37 from material secreted by those cells. This distinguishes the precursor protein from the shorter peptide released from it.
[Human hCAP18 processing study, 2001](https://pubmed.ncbi.nlm.nih.gov/11389039/)
Those with recurring infections · Anyone recovering from wounds · Those with respiratory issues · Immune-compromised individuals
In-stock prices from 73 vendors, checked Oct 14, 2026.
Market evidence
We found certificates from some of the LL-37 vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Certificate assessment
1 evaluated certificates
1 graded · 0 not graded · 1 in the A range.
Each result belongs to the named vendor’s certificate. Grades assess the document and its reported tests, not the vendor’s whole catalog or the safety of a product.
Automated checks can make mistakes. Open “Why this result?” for the reason and any review notice, and check the linked COA’s lot against your product. How grading works
1 evaluated record
Document grade
C3: We couldn't confirm this certificate against the lab's own records, so the grade stops at A-.
Document check: flag.
Lab record: not confirmed.
Graded Oct 14, 2026 · Grader 0.4.9 · Policy 2026-10-07.2
LL051026
| COA grade | Printed lab | Certificate | |||
|---|---|---|---|---|---|
| retaone Lot: LL051026 | Document grade Why this result?C3: We couldn't confirm this certificate against the lab's own records, so the grade stops at A-. Document check: flag. Lab record: not confirmed. Graded Oct 14, 2026 · Grader 0.4.9 · Policy 2026-10-07.2 | KOVERA LABS | Oct 6, 2026 | 99.846%99.5%+ | View COA |
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