Cognitive Category
MIF-1
THE MOOD MODULATOR
Melanocyte-Inhibiting Factor; PLG
MIF-1 (Pro-Leu-Gly-NH2) is a naturally occurring tripeptide derived from oxytocin that can cross the blood-brain barrier and influence your dopamine system. It shows rapid antidepressant effects in studies and may help with mood, cognition, and even Parkinson's symptoms. It's also being researched for helping reduce opioid dependence.
MIF-1 Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- May 8, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About MIF-1
Is MIF-1 FDA approved?
No. This profile records MIF-1 as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for MIF-1?
Dose: 50-200 mcg daily (intranasal or injection).
More context
Schedule: daily. Cycle: 4-8 weeks on, 4 weeks break. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this MIF-1 guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the MIF-1 research sourcesStudied Effects & Mechanisms
Dopamine Modulation
Enhances dopamine D2/D4 receptor signaling
Endorphin Release
Stimulates natural endorphin production for mood lift
Neuroprotection
May protect neurons and support brain health
NMDA Regulation
Down-regulates NMDA receptors, reducing excitotoxicity
Who is this for
Those dealing with low mood or depression · People seeking natural cognitive enhancement · Those interested in dopamine system support · People recovering from opioid dependence · Anyone wanting mood stability without SSRIs
Research-Market Price Snapshot
A compact market signal for this profile. The dedicated pricing page owns vendor, vial-size, and price-per-mg comparisons.
Updated Aug 3, 2026
- Vendors
- 1
- Listings
- 1
- Observed range
- $138–$138
Market evidence
MIF-1 product testing and COAs
Current certificates are on file for 0 of 1 vendors tracked in the MIF-1 market. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
MIF-1 Research
Live research temporarily unavailable
The live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
Research references
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