Cognitive Category
MIF-1
THE MOOD MODULATOR
Melanocyte-Inhibiting Factor; PLG
MIF-1 (Pro-Leu-Gly-NH2) is a naturally occurring tripeptide derived from oxytocin that can cross the blood-brain barrier and influence your dopamine system. It shows rapid antidepressant effects in studies and may help with mood, cognition, and even Parkinson's symptoms. It's also being researched for helping reduce opioid dependence.
MIF-1 Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- Sources pending
- Content updated
- May 8, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly.
Quick Answers About MIF-1
Is MIF-1 FDA approved?
No. This profile records MIF-1 as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for MIF-1?
Dose: 50-200 mcg daily (intranasal or injection).
More context
Schedule: daily. Cycle: 4-8 weeks on, 4 weeks break. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this MIF-1 guide?
No linked research sources are currently available on this guide.
More context
Treat the profile as provisional until supporting sources are published.
What are the side effects of MIF-1?
We don't list specific side effects for MIF-1.
Is MIF-1 safe?
MIF-1 has an editorial safety grade of A (Excellent Safety).
More context
Well tolerated in studies with no major adverse effects noted. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
Dopamine Modulation
Enhances dopamine D2/D4 receptor signaling
Endorphin Release
Stimulates natural endorphin production for mood lift
Neuroprotection
May protect neurons and support brain health
NMDA Regulation
Down-regulates NMDA receptors, reducing excitotoxicity
Who is this for
Those dealing with low mood or depression · People seeking natural cognitive enhancement · Those interested in dopamine system support · People recovering from opioid dependence · Anyone wanting mood stability without SSRIs
Market evidence
MIF-1 product testing and COAs
We have not assessed certificate coverage for MIF-1 yet. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
The clinic network
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