Longevity Category
Matrixyl
THE WRINKLE ERASER
Palmitoyl Pentapeptide-4 (Pal-KTTKS)
Matrixyl is a cosmetic peptide that mimics the fragments your skin produces when collagen breaks down. These "matrikine" signals tell your skin cells (fibroblasts) to produce more collagen, elastin, and hyaluronic acid. It's one of the most clinically-studied anti-wrinkle peptides and is found in many premium skincare products.
Matrixyl Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- Reviewed by our clinical team
- Linked evidence
- 1 research sources
- Content updated
- May 8, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Matrixyl
Is Matrixyl FDA approved?
No. This profile records Matrixyl as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What dose does The Peptide App Clinical Team recommend for Matrixyl?
Dose: 0.5-2% concentration in topical products, applied twice daily.
More context
Schedule: daily. Cycle: Ongoing daily use. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Matrixyl guide?
This guide links to 1 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Matrixyl research sourcesStudied Effects & Mechanisms
Collagen Stimulation
Signals fibroblasts to produce new collagen
Elastin Production
Increases elastin synthesis for skin elasticity
Hydration Boost
Enhances hyaluronic acid and GAG production
Matrix Repair
Mimics wound-healing signals to rebuild skin matrix
Who is this for
Those concerned about wrinkles and fine lines · People wanting to improve skin firmness · Anyone seeking non-invasive anti-aging · Those with sun-damaged skin · People looking for science-backed skincare
Commonly Stacked With
Research-Market Price Snapshot
A compact market signal for this profile. The dedicated pricing page owns vendor, vial-size, and price-per-mg comparisons.
Updated Aug 30, 2026
- Vendors
- 7
- Listings
- 7
- Observed range
- $19–$190
Market evidence
Matrixyl product testing and COAs
Current certificates are on file for 3 of 7 vendors tracked in the Matrixyl market. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Matrixyl Research
Live research temporarily unavailable
The live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
Research references
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