Metabolic Category
Adipotide
THE FAT BURNER
FTPP, FTTP, Prohibitin-Targeting Peptide
Adipotide is an experimental peptide that takes a unique approach to fat loss. It literally kills fat cells by targeting the blood vessels that feed them. Unlike other weight loss peptides that suppress appetite, Adipotide causes fat cell death (apoptosis) by binding to prohibitin on blood vessel cells in fatty tissue. This is a more aggressive approach and should be considered experimental.
Adipotide Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- No established regimen
- Linked evidence
- 4 research sources
- Content updated
- Sep 15, 2026
Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Adipotide
Is Adipotide FDA approved?
No. This profile records Adipotide as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What research supports this Adipotide guide?
This guide links to 4 curated or current research sources.
More context
Inspect the research section and the citations beneath the research answers for their supporting sources.
Review the Adipotide research sourcesWhat are the side effects of Adipotide?
Reported side effects of Adipotide include Kidney stress, Dehydration, Fatigue, and Injection site reactions.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Adipotide safe?
Adipotide has an editorial safety grade of C (Experimental).
More context
Limited human data. Animal studies showed effectiveness but also kidney stress. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
What is adipotide?
Adipotide is a ligand-directed peptidomimetic with the sequence CKGGRAKDC-GG-(D)(KLAKLAK)(2). It is a bioconjugate composed of a prohibitin-targeting peptide and the proapoptotic peptide KLA. In an animal study, adipotide was evaluated in obese Old World monkeys. The paper compares it with the prohibitin-targeted nanoparticle (PTNP) encapsulating KLA, called KLA-PTNP.
What does adipotide peptide do to fat tissue?
In obese monkeys, treatment with adipotide induced targeted apoptosis (cell death) within blood vessels of white adipose tissue. That study also reported rapid weight loss and improved insulin resistance in the monkeys. A comment on the study describes adipotide as a peptidomimetic that reduces weight by inducing apoptosis of blood vessels surrounding white adipose tissue, but says the weight loss may instead reflect a direct effect of adipotide on food consumption.
Studied Effects & Mechanisms
Vascular Homing
Specifically targets blood vessels supplying fat tissue
Apoptosis Induction
Triggers cell death in fat tissue vasculature
Fat Cell Death
Adipocytes die when blood supply is cut off
A peptide assembled from two domains
The 2011 report by Barnhart and colleagues at the University of Texas MD Anderson Cancer Center describes adipotide as a joined peptide construct. It combines the CKGGRAKDC targeting sequence, a two-glycine linker, and two copies of KLAKLAK made with D-amino acids. This domain-based construction is the basis of its description as a chimeric peptidomimetic.
[Barnhart and colleagues, adipotide construct, 2011](https://pmc.ncbi.nlm.nih.gov/articles/PMC3666164/)
Who is this for
Those seeking aggressive fat loss · People who haven't responded to other methods · Those comfortable with experimental compounds
Adipotide price snapshot
In-stock prices from 23 vendors, checked Oct 14, 2026.
- Vendors
- 23
- Listings
- 29
- Observed range
- $24–$215
Market evidence
Adipotide product testing and COAs
We found certificates from some of the Adipotide vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Adipotide research
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