Semaglutide
Take control of your appetite and transform your body with proven science.
Read the full profileThree-way comparison
SemaglutidevsTirzepatidevsRetatrutide
Compare semaglutide, tirzepatide, and retatrutide side by side, including dosing, titration, safety information, and common side effects.
Three peptide profilesSame categoriesReviewed July 24, 2026
01Short answer
Semaglutide, tirzepatide, and retatrutide are different compounds.
The page shows the same profile information for each one. It does not rank them, recommend one, or determine whether starting, switching, or combining them is appropriate.
02
Peptide profiles
Semaglutide, tirzepatide, and retatrutide
Tirzepatide
The ultimate FDA-approved weight loss solution. Lose 20%+ of your body weight.
Read the full profileRetatrutide
The most powerful weight loss solution available, with 24% average weight loss in trials.
Read the full profile03
Side by side
Compare the key details
Overview
Semaglutide is an FDA-approved GLP-1 receptor agonist that has transformed treatment of obesity and type 2 diabetes. It works by mimicking the hormone GLP-1 to reduce appetite, slow stomach emptying, and improve insulin sensitivity. In trials, it produced 15% weight los...
Tirzepatide is a dual peptide that mimics GLP-1 and GIP to powerfully suppress appetite, slow digestion, and improve insulin sensitivity, helping many people lose significant weight and control blood sugar.
Retatrutide is a triple-action peptide that tells your body to eat less, burn more calories through glucagon, and improve blood sugar control, all in one molecule for powerful weight and metabolic effects.
Safety
Grade B · Good Safety
FDA-approved with well-characterized side effects. GI issues are common but manageable.
Contraindicated in medullary thyroid cancer or MEN 2 syndrome. May cause pancreatitis. Do not mix in the same syringe as other peptides. Inject GLP-1s on their own.
Grade A · Excellent Safety
FDA-approved with extensive clinical trial data. Well-characterized side effect profile.
Common GI side effects typically improve over 4-8 weeks. Titrate slowly to minimize nausea. Not for Type 1 diabetes. Do not mix in the same syringe as other peptides. Inject GLP-1s on their own.
Grade C · Moderate Safety
Still in clinical trials. GI side effects are common but manageable.
Investigational drug - not yet approved. Titrate slowly to minimize side effects. Do not mix in the same syringe as other peptides. Inject GLP-1s on their own.
Profile dosing context
Injection: Start 0.25 mg weekly, titrate to 1-2.4 mg weekly. Oral: Start 3 mg daily, up to 14 mg daily
weekly
Ongoing as prescribed
Titrate slowly over months to minimize GI side effects; take oral on empty stomach
2.5 mg weekly, titrating up every 4 weeks
weekly
12-24 weeks per treatment cycle
Start at 2.5 mg and increase slowly (every 4 weeks) to minimize GI side effects. Take at the same time each week.
Start at 0.5 mg weekly, titrate to 2.5-5 mg weekly
weekly
12 weeks on, 12 weeks off (per clinical trials)
Slow titration is key - increase dose every 4 weeks to minimize GI effects
Requires titration
Yes
Yes
Yes
Occasional side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Injection site reactions
- Nausea
- Vomiting
- Diarrhea
- Reduced appetite
- Constipation
- Indigestion
- Injection site reactions
- Nausea
- Vomiting
- Diarrhea
- Injection site irritation
How to read this page
Each section shows the same type of information for all three peptides. The data comes from their individual profiles. When a profile does not include a value, the page shows a dash.
- Semaglutide
- Take control of your appetite and transform your body with proven science.
- Tirzepatide
- The ultimate FDA-approved weight loss solution. Lose 20%+ of your body weight.
- Retatrutide
- The most powerful weight loss solution available, with 24% average weight loss in trials.
Common questions
What is the difference between semaglutide, tirzepatide, and retatrutide?
They are distinct compounds with different dosing notes, evidence, safety information, and side-effect profiles. This page compares the same categories for each one so you can review the differences directly.
Which of the three is better?
There is no universal answer, and this page does not recommend or rank them. Product status, evidence, safety, and individual context all matter; a licensed professional is the right person to interpret those factors.
Can semaglutide, tirzepatide, and retatrutide be combined?
This comparison should not be used to start, stop, switch, or combine protocols. Combining compounds can change dosing complexity and risk, so a licensed professional should evaluate whether any combination is appropriate.
This comparison is for research and educational purposes. It does not diagnose, treat, prescribe, or replace guidance from a licensed professional. Always follow the instructions provided with your product.
Protocol tracking
Open the appTrack your protocol in The Peptide App.
Keep dose timing, reminders, and protocol notes together in The Peptide App.