Healing Category
Larazotide
THE GUT SEALER
AT-1001; Larazotide Acetate
Larazotide is designed to close the gaps between intestinal cells that cause "leaky gut." It blocks zonulin, a protein that opens these gaps and allows food particles and bacteria to leak into your bloodstream. Originally developed for celiac disease, it may help anyone with intestinal permeability issues.
Larazotide Evidence Snapshot
How these guides are reviewed- Regulatory status
- Not FDA approved · research use only
- Dosing guidance
- No established regimen
- Linked evidence
- 2 research sources
- Content updated
- Sep 15, 2026
Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Larazotide
Is Larazotide FDA approved?
No. This profile records Larazotide as not FDA approved and for research use only.
More context
Review the regulatory and source details on this page for the current context.
What research supports this Larazotide guide?
This guide links to 2 curated or current research sources.
More context
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Review the Larazotide research sourcesWhat are the side effects of Larazotide?
Reported side effects of Larazotide include Occasional nausea and Mild abdominal discomfort.
More context
They are reported or occasional reactions, not a prediction of what any one person will experience.
Is Larazotide safe?
Larazotide has an editorial safety grade of A (Excellent Safety).
More context
Well-tolerated in clinical trials with minimal side effects. Safety depends on dose, sourcing, health history and medical supervision, so this page does not call it safe for personal use.
Studied Effects & Mechanisms
Zonulin Blocker
Prevents zonulin from opening tight junctions
Barrier Restoration
Keeps intestinal cells tightly connected
Inflammation Reduction
Reduces immune activation from leaked antigens
Eight-residue peptide research
Larazotide is a synthetic peptide containing eight amino acids. Its discovery came from screening synthetic peptides related to Vibrio cholerae, rather than isolating a human hormone. Alba Therapeutics researchers subsequently described it in epithelial-cell experiments published in 2012, providing part of the laboratory history behind the compound.
[Larazotide discovery background in the 2015 trial report](https://pmc.ncbi.nlm.nih.gov/articles/PMC4446229/)
[Alba Therapeutics laboratory study, 2012](https://pubmed.ncbi.nlm.nih.gov/22401910/)
Who is this for
People with celiac disease · Those with leaky gut syndrome · Crohn's disease patients · Anyone with food sensitivities · People with IBS
Market evidence
Larazotide product testing and COAs
We found certificates from most of the Larazotide vendors we track. Based on the certificates our crawler found; vendors may publish more than we index. Research on this page describes the molecule. Vendor certificates concern particular market samples or batches; they do not change the research evidence or establish clinical safety, sterility, or suitability for use.
Larazotide research
The clinic network
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